PRODUCT SEARCH
Enquiries
If you have any questions about products featured on this site, or on products that you cannot find on this site, please contact us and we will be happy to assist you in any way that we can. We have a team of technical sales specialists who are waiting to hear from you!
Contact UsHome > Filter-Aids-Diatomaceous-Earth > GMP Filter Aid > AW Celite NF
AW Celite NF
AW Celite NF Media is a high purity, direct replacement for conventional (Food Grade) Celite Diatomite filter aids. AW Celite NF media is the best choice where a high purity, USP-NF Grade direct replacement is needed for conventional food grade Celite filter aids. With the exception of the acid washing step, the AW Celite manufacturing process is similar to that of conventional Celite filter aids. This similarity produces a media that will minimize differences in filtration processes that previously used Food grades.
Studies show that after replacing Food Grade Celite filter aids with AW Celite NF media, extractable impurities are significantly reduced (Table 1).
| Celite Standard Super-Cel® (Food grade) |
AW Celite Standard Super-Cel® NF (High Purity grade) |
|
|---|---|---|
| Al | 84.1 | 0.4 |
| Ca | 52.5 | nd |
| Mg | 50.5 | 7.4 |
| Fe | 20.0 | 1.4 |
| Zn | 10.5 | nd |
| Cu | 0.8 | 0.6 |
| Sb | 0.6 | 0.01 |
| Mn | 0.7 | 0.1 |
| Cr | 0.2 | 0.1 |
| *(nd) Below detectable limit | ||
Table 1. Extractable analysis by ICP-MS except for Fe (colorimetric complex with 1,10-phenanthroline). Extractables expressed as mg/kg of filter aid extracted from 2-g samples incubated in 100-mL solutions. Solution: 10 mg/mL albumin, 50 mM sodium acetate, pH 4.3. Incubation: 4 h, 160 rpm, 50oC.
AW Celite NF media was developed as a pharmaceutical grade CGMP alternative to Food Grade Celite. AW Celite NF media addresses the following CGMP needs that are unmet with Food Grade diatomite filter aids:
Regulatory Support
Compendial standards
Purity
Manufacturing and process control
Packaging
For more information on the differences between AW Celite NF and Food grades of diatomite see Filter Aid in CGMP Parenteral Pharmaceutical Processing: A Regulatory Perspective and Replacing Food Grade Celite® Media with AW Celite NF Media in CGMP Pharmaceutical Processes.
Intended Use of AW Celite® Media
AW Celite NF media is intended for solid-liquid separation in conjunction with a pressure filtration system. AW Celite NF media is available in a wide range of permeabilities. The least-permeable AW Celite NF Grades can remove submicron solids in filtration applications (Table 2).
| High Purity Grade | Permeability (Darcy) | Solids Removed (micron)* |
|---|---|---|
| AW Celite Filter Cel® NF | 84.1 | 0.4 |
| AW Celite® 521 NF | 52.5 | nd |
| AW Standard Super-Cel® NF | 50.5 | 7.4 |
| AW Celite® 512 NF | 20.0 | 1.4 |
| AW Hyflo Super-Cel® NF | 10.5 | nd |
| AW Celite® 503 NF | 0.8 | 0.6 |
| AW Celite® 535 NF | 0.6 | 0.01 |
| AW Celite® 545 NF | 0.7 | 0.1 |
Table 2. *Data is provided for comparison purposes only. Depending on the compressibility of the solids, the values may range by more than an order of magnitude.
- DownloadBrochure
RELATED PRODUCTS
-
Celpure
Celpure Diatomite is a High Purity Filter Aid intended for critical applications in the API, high purity chemical, and pharmaceutical, biotech and veterinary applications. Celpure patented manufacturing process is a major advance in filter aid technology and produced in a standalone FDA approved facility.
View Details
-
MP2 Harborlite
MP2 Harborlite media is the preferred choice where a High Purity, direct replacement is needed for Food Grade Harborlite perlite filter aid. With the exception of the acid washing purification step, the MP2 Harborlite perlite manufacturing process is similar to that of conventional Harborlite perlite filter aid. This similarity produces a media that minimises differences in filtration processes.
View Details